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KMID : 0383819810280010040
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Tuberculosis and Respiratory Diseases
1981 Volume.28 No. 1 p.40 ~ p.43
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Immunity in Tuberculosis
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Chaparase Sotiros D.
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Abstract
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Mycobacteria which produce disease in man are listed in Table 1. Tuberculosis is the most important of these diseases.
Tuberculosis in Korea remains high relative to other nations in the world. The effectiveness. of BCG vaccine as prophylactic measure against tuberculosis has recently been questioned after analysis of results of a seven year trial in South India. The trial employed two dose levels of the French and Danish strains administered randomly and in a double-blind fashion to 260,000 subjects. Vaccination did not appear to convey any protection. There are factors with the trial which were not adequately considered and it is not proper to condemn BCG vaccines as inefficacious. The most glaring factor is the presence of nontuberculous mycobacteria in the study area. Nontuberculous mycobacteria sensitize and protect populations against tuberculosis. BCG vaccination does not appear to add protection beyond that already induced by other mycobacterial infections. Antigenic sharing among species of mycobacteria is extensive as can be seen in figure. Of the numerous shared antigens a number are likely to be immunogenic.
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